General Information of the Compound
Compound ID
CP0290321
Compound Name
Methylhistaprodifen
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Synonyms
N-methylhistaprodifen
methylhistaprodifen
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Structure
Formula
C21H25N3
Molecular Weight
319.452
Canonical SMILES
CNCCc1cnc(CCC(c2ccccc2)c2ccccc2)[nH]1
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InChI
InChI=1S/C21H25N3/c1-22-15-14-19-16-23-21(24-19)13-12-20(17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11,16,20,22H,12-15H2,1H3,(H,23,24)
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InChIKey
YMVWDVNGNLXSKR-UHFFFAOYSA-N
Physicochemical Property
logP
3.9363
Rotatable Bonds
8
Heavy Atom Count
24
Polar Areas
40.71
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10403687
SID: 15420770
ChEMBL ID
CHEMBL275035
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01065, Serine/threonine-protein kinase mTOR
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL001056 MEF-1 [Mouse fibroblast] Mus musculus (Mouse)  1
1
Potency = 11668.1 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( methylhistaprodifen )
Drug Name methylhistaprodifen
Target(s)
Histamine H1 receptor (H1R)
Agonist