General Information of the Compound
Compound ID
CP0281301
Compound Name
N-[[1-(diethylamino)cyclopentyl]methyl]-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide
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Structure
Formula
C27H36N6O2
Molecular Weight
476.625
Canonical SMILES
CCN(CC)C1(CNC(=O)N2CCC(CC2)c2nc(no2)-c2ccc3ccccc3n2)CCCC1
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InChI
InChI=1S/C27H36N6O2/c1-3-33(4-2)27(15-7-8-16-27)19-28-26(34)32-17-13-21(14-18-32)25-30-24(31-35-25)23-12-11-20-9-5-6-10-22(20)29-23/h5-6,9-12,21H,3-4,7-8,13-19H2,1-2H3,(H,28,34)
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InChIKey
CMRWSKARFINBQJ-UHFFFAOYSA-N
Physicochemical Property
logP
4.8284
Rotatable Bonds
7
Heavy Atom Count
35
Polar Areas
87.39
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56661560
ChEMBL ID
CHEMBL1822443
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  2
1
IC50 = 46 nM
   TI
   LI
   LO
   TS
2
IC50 = 55 nM
   TI
   LI
   LO
   TS