General Information of the Compound
Compound ID
CP0281148
Compound Name
TANAPROGET
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Synonyms
1zuc
304853-42-7
5-(4,4-Dimethyl-2-thioxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-1-methyl-1H-pyrrole-2-carbonitrile
AC1NA08O
AKOS030526776
BDBM50375821
CHEMBL539163
CS-1550
D06003
DB04787
DTXSID00184556
FT-0735521
GTPL7416
HY-15606
KB-145966
NSP 989
NSP-989
NSP-989;NSP 989;NSP989
PYVFWTPEBMRKSR-UHFFFAOYSA-N
SB17247
SCHEMBL62188
T98
Tanaproget
Tanaproget (USAN/INN)
Tanaproget [USAN:INN]
UNII-W9F9H8GXWR
W-5758
W9F9H8GXWR
ZINC6245719
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Structure
Formula
C16H15N3OS
Molecular Weight
297.383
Canonical SMILES
Cn1c(ccc1-c1ccc2NC(=S)OC(C)(C)c2c1)C#N
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InChI
InChI=1S/C16H15N3OS/c1-16(2)12-8-10(4-6-13(12)18-15(21)20-16)14-7-5-11(9-17)19(14)3/h4-8H,1-3H3,(H,18,21)
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InChIKey
PYVFWTPEBMRKSR-UHFFFAOYSA-N
CAS
304853-42-7
Physicochemical Property
logP
3.52588
Rotatable Bonds
1
Heavy Atom Count
21
Polar Areas
49.98
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
21

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 4369524
SID: 14849432
ChEMBL ID
CHEMBL539163
DrugBank ID
DB04787
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  2
1
EC50 = 0.15 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.5 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Tanaproget )
Drug Name Tanaproget
Indication
Estrogen deficiency
Investigative
Target(s)
Progesterone receptor (PGR)
Inhibitor