General Information of the Compound
Compound ID
CP0280315
Compound Name
5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol
    Show/Hide
Synonyms
5,11-Dimethyl-6H-pyrido(4,3-b)carbazol-9-ol
5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol
5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol
51131-85-2
6H-Pyrido(4,3-b)carbazol-9-ol, 5,11-dimethyl-
6H-Pyrido[4,3-b]carbazol-9-ol, 5,11-dimethyl-
9-Hydroxyellipticin
9-Hydroxyellipticine
9-hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole
9G4A3ET6XG
C17H14N2O
CHEBI:88297
CHEMBL26559
EINECS 257-000-0
ELLIPTICINE, 9-HYDROXY-
Hydroxy-9 ellipticine
Hydroxy-9 ellipticine [French]
Hydroxyellipticine
IGIG 929
NSC 210717
NSC 237070
UNII-9G4A3ET6XG
    Show/Hide
Structure
Formula
C17H14N2O
Molecular Weight
262.312
Canonical SMILES
Cc1c2[nH]c3ccc(O)cc3c2c(C)c2cnccc12
    Show/Hide
InChI
InChI=1S/C17H14N2O/c1-9-14-8-18-6-5-12(14)10(2)17-16(9)13-7-11(20)3-4-15(13)19-17/h3-8,19-20H,1-2H3
    Show/Hide
InChIKey
QZTWUDDGLIDXSE-UHFFFAOYSA-N
Physicochemical Property
logP
4.19174
Rotatable Bonds
0
Heavy Atom Count
20
Polar Areas
48.91
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
20

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 91643
SID: 14750221
ChEMBL ID
CHEMBL26559
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00888, Mast/stem cell growth factor receptor Kit
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000755 Ba/F3 c-Kit D816V
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 10 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( 5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol )
Drug Name 5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol
Target(s)
Platelet-derived growth factor receptor alpha (PDGFRA)
 Target Info 
Inhibitor
Fibroblast growth factor receptor 3 (FGFR3)
 Target Info 
Inhibitor
Tyrosine-protein kinase Kit (KIT)
 Target Info 
Inhibitor