General Information of the Compound
Compound ID
CP0274882
Compound Name
2-({2-[(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]benzene}sulfonamido)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
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Structure
Formula
C27H37N3O4S
Molecular Weight
499.677
Canonical SMILES
CN1C(C)(C)CC(CC1(C)C)Nc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
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InChI
InChI=1S/C27H37N3O4S/c1-26(2)16-19(17-27(3,4)30(26)5)28-21-12-8-9-13-23(21)35(33,34)29-22-15-14-18-10-6-7-11-20(18)24(22)25(31)32/h8-9,12-15,19,28-29H,6-7,10-11,16-17H2,1-5H3,(H,31,32)
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InChIKey
GRJIKPWOWUZNJG-UHFFFAOYSA-N
Physicochemical Property
logP
5.1277
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
98.74
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11511667
SID: 16613565
ChEMBL ID
CHEMBL211453
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00973, Methionine aminopeptidase 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
EC50 = 18000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 91 nM
2 IC50 <= 4600 nM