General Information of the Compound
Compound ID
CP0264050
Compound Name
2-(benzylamino)-4-(4-methylpiperazin-1-yl)benzonitrile
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Structure
Formula
C19H22N4
Molecular Weight
306.413
Canonical SMILES
CN1CCN(CC1)c1ccc(C#N)c(NCc2ccccc2)c1
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InChI
InChI=1S/C19H22N4/c1-22-9-11-23(12-10-22)18-8-7-17(14-20)19(13-18)21-15-16-5-3-2-4-6-16/h2-8,13,21H,9-12,15H2,1H3
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InChIKey
HZHGVNZFZLEQOX-UHFFFAOYSA-N
Physicochemical Property
logP
2.92218
Rotatable Bonds
4
Heavy Atom Count
23
Polar Areas
42.3
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11601955
SID: 16704681
ChEMBL ID
CHEMBL250401
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 108 nM
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