General Information of the Compound
Compound ID
CP0248431
Compound Name
2-(2-azabicyclo[2.1.1]hexan-1-yl)-6-(5-methyl-1H-pyrazol-4-yl)-3H-thieno[3,2-d]pyrimidin-4-one;dihydrochloride
    Show/Hide
Structure
Formula
C15H17Cl2N5OS
Molecular Weight
386.308
Canonical SMILES
Cl.Cl.Cc1n[nH]cc1-c1cc2nc([nH]c(=O)c2s1)C12CC(C1)CN2
    Show/Hide
InChI
InChI=1S/C15H15N5OS.2ClH/c1-7-9(6-17-20-7)11-2-10-12(22-11)13(21)19-14(18-10)15-3-8(4-15)5-16-15;;/h2,6,8,16H,3-5H2,1H3,(H,17,20)(H,18,19,21);2*1H
    Show/Hide
InChIKey
MOGPGPGVPDQCHY-UHFFFAOYSA-N
Physicochemical Property
logP
2.73522
Rotatable Bonds
2
Heavy Atom Count
24
Polar Areas
86.46
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 155512073
ChEMBL ID
CHEMBL4436649
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00985, Cell division cycle 7-related protein kinase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000017 HeLa Homo sapiens (Human)  1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS