General Information of the Compound
Compound ID
CP0245147
Compound Name
2-(7-(2-(4-(trifluoromethyl)benzyloxy)benzylthio)-2,3-dihydro-1H-inden-4-yloxy)acetic acid
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Structure
Formula
C26H23F3O4S
Molecular Weight
488.527
Canonical SMILES
OC(=O)COc1ccc(SCc2ccccc2OCc2ccc(cc2)C(F)(F)F)c2CCCc12
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InChI
InChI=1S/C26H23F3O4S/c27-26(28,29)19-10-8-17(9-11-19)14-32-22-7-2-1-4-18(22)16-34-24-13-12-23(33-15-25(30)31)20-5-3-6-21(20)24/h1-2,4,7-13H,3,5-6,14-16H2,(H,30,31)
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InChIKey
UQDCLZWSSZJCMF-UHFFFAOYSA-N
Physicochemical Property
logP
6.5288
Rotatable Bonds
9
Heavy Atom Count
34
Polar Areas
55.76
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 22280178
ChEMBL ID
CHEMBL234665
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00909, Peroxisome proliferator-activated receptor delta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 230 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 10.4 nM