General Information of the Compound
Compound ID
CP0243955
Compound Name
2-cyclopropyl-N-(2-methoxyethyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]-N-methylquinazolin-6-amine
    Show/Hide
Structure
Formula
C27H34N4O2
Molecular Weight
446.595
Canonical SMILES
COCCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3OC)c2c1)C1CC1
    Show/Hide
InChI
InChI=1S/C27H34N4O2/c1-30(16-17-32-2)21-10-11-24-23(18-21)27(29-26(28-24)20-8-9-20)31-14-12-19(13-15-31)22-6-4-5-7-25(22)33-3/h4-7,10-11,18-20H,8-9,12-17H2,1-3H3
    Show/Hide
InChIKey
DROZWECPKCAFDI-UHFFFAOYSA-N
Physicochemical Property
logP
4.9824
Rotatable Bonds
8
Heavy Atom Count
33
Polar Areas
50.72
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 90237648
ChEMBL ID
CHEMBL4593175
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02429, Neurotensin receptor type 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1 Cricetulus griseus (Chinese hamster)  1
1
EC50 = 1120 nM
   TI
   LI
   LO
   TS