General Information of the Compound
Compound ID
CP0242684
Compound Name
N-[1-[[(3S,4R)-1-(cyclopentanecarbonyl)-4-hydroxy-4-phenylpyrrolidin-3-yl]methyl]piperidin-4-yl]-2-phenyl-N-prop-2-enylacetamide
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Structure
Formula
C33H43N3O3
Molecular Weight
529.725
Canonical SMILES
O[C@@]1(CN(C[C@@H]1CN1CCC(CC1)N(CC=C)C(=O)Cc1ccccc1)C(=O)C1CCCC1)c1ccccc1
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InChI
InChI=1S/C33H43N3O3/c1-2-19-36(31(37)22-26-11-5-3-6-12-26)30-17-20-34(21-18-30)23-29-24-35(32(38)27-13-9-10-14-27)25-33(29,39)28-15-7-4-8-16-28/h2-8,11-12,15-16,27,29-30,39H,1,9-10,13-14,17-25H2/t29-,33-/m0/s1
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InChIKey
JLQHXHOVRNSYGX-ZQAZVOLISA-N
Physicochemical Property
logP
4.2445
Rotatable Bonds
9
Heavy Atom Count
39
Polar Areas
64.09
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49798129
ChEMBL ID
CHEMBL1172157
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 3.5 nM
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