General Information of the Compound
Compound ID
CP0232986
Compound Name
5-[(3S)-3-[(3-chloro-5-fluorophenyl)methylcarbamoyl]-3-hydroxy-2-oxopyrrolidin-1-yl]-N-ethyl-1H-indole-2-carboxamide
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Structure
Formula
C23H22ClFN4O4
Molecular Weight
472.904
Canonical SMILES
CCNC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O
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InChI
InChI=1S/C23H22ClFN4O4/c1-2-26-20(30)19-10-14-9-17(3-4-18(14)28-19)29-6-5-23(33,22(29)32)21(31)27-12-13-7-15(24)11-16(25)8-13/h3-4,7-11,28,33H,2,5-6,12H2,1H3,(H,26,30)(H,27,31)/t23-/m0/s1
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InChIKey
TUPCUCNBNOUJJC-QHCPKHFHSA-N
Physicochemical Property
logP
2.4943
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
114.53
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 89855793
ChEMBL ID
CHEMBL4445117
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00973, Methionine aminopeptidase 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000749 HUVEC-C Homo sapiens (Human)  1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 41 nM