General Information of the Compound
Compound ID
CP0232638
Compound Name
2-[4-[[3-(2,6-dichlorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]methoxy]phenyl]-3-heptan-4-ylbenzimidazole-5-carboxylic acid
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Structure
Formula
C34H35Cl2N3O4
Molecular Weight
620.577
Canonical SMILES
CCCC(CCC)n1c(nc2ccc(cc12)C(O)=O)-c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C(C)C)cc1
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InChI
InChI=1S/C34H35Cl2N3O4/c1-5-8-23(9-6-2)39-29-18-22(34(40)41)14-17-28(29)37-33(39)21-12-15-24(16-13-21)42-19-25-31(38-43-32(25)20(3)4)30-26(35)10-7-11-27(30)36/h7,10-18,20,23H,5-6,8-9,19H2,1-4H3,(H,40,41)
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InChIKey
PIBDDGSPCWTTPC-UHFFFAOYSA-N
Physicochemical Property
logP
10.207
Rotatable Bonds
12
Heavy Atom Count
43
Polar Areas
90.38
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156012458
ChEMBL ID
CHEMBL4637834
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01286, Bile acid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
EC50 = 1.8 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 30.3 nM
Protein ID: PT02378, Vitamin D3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS