General Information of the Compound
Compound ID
CP0224407
Compound Name
1-[4-[2-[[6-[4-[3-(dimethylamino)propoxy]phenyl]furo[2,3-d]pyrimidin-4-yl]amino]ethyl]phenyl]-3-phenylurea
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Structure
Formula
C32H34N6O3
Molecular Weight
550.663
Canonical SMILES
CN(C)CCCOc1ccc(cc1)-c1cc2c(NCCc3ccc(NC(=O)Nc4ccccc4)cc3)ncnc2o1
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InChI
InChI=1S/C32H34N6O3/c1-38(2)19-6-20-40-27-15-11-24(12-16-27)29-21-28-30(34-22-35-31(28)41-29)33-18-17-23-9-13-26(14-10-23)37-32(39)36-25-7-4-3-5-8-25/h3-5,7-16,21-22H,6,17-20H2,1-2H3,(H,33,34,35)(H2,36,37,39)
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InChIKey
AWSFTVYABIVKMR-UHFFFAOYSA-N
Physicochemical Property
logP
6.5189
Rotatable Bonds
12
Heavy Atom Count
41
Polar Areas
104.55
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57946419
ChEMBL ID
CHEMBL2398643
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00980, Aurora kinase A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 61 nM
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