General Information of the Compound
Compound ID
CP0199852
Compound Name
2-(6-((5-(4-chlorophenyl)isoxazol-3-yl)methoxy)-4-methylbenzo[b]thiophen-3-yl)acetic acid
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Structure
Formula
C21H16ClNO4S
Molecular Weight
413.882
Canonical SMILES
Cc1cc(OCc2cc(on2)-c2ccc(Cl)cc2)cc2scc(CC(O)=O)c12
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InChI
InChI=1S/C21H16ClNO4S/c1-12-6-17(9-19-21(12)14(11-28-19)7-20(24)25)26-10-16-8-18(27-23-16)13-2-4-15(22)5-3-13/h2-6,8-9,11H,7,10H2,1H3,(H,24,25)
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InChIKey
GTZMHMRAOJUYKJ-UHFFFAOYSA-N
Physicochemical Property
logP
5.72422
Rotatable Bonds
6
Heavy Atom Count
28
Polar Areas
72.56
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 22504917
ChEMBL ID
CHEMBL391085
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00909, Peroxisome proliferator-activated receptor delta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 638 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 23 nM