General Information of the Compound
Compound ID
CP0198590
Compound Name
4-[(2S)-2-(1,6-dimethylbenzimidazol-2-yl)-2-[2,5-dioxo-3-(4-phenoxyphenyl)imidazolidin-1-yl]ethyl]-N-propan-2-ylbenzamide
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Structure
Formula
C36H35N5O4
Molecular Weight
601.707
Canonical SMILES
CC(C)NC(=O)c1ccc(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccc(C)cc3n2C)cc1
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InChI
InChI=1S/C36H35N5O4/c1-23(2)37-35(43)26-13-11-25(12-14-26)21-32(34-38-30-19-10-24(3)20-31(30)39(34)4)41-33(42)22-40(36(41)44)27-15-17-29(18-16-27)45-28-8-6-5-7-9-28/h5-20,23,32H,21-22H2,1-4H3,(H,37,43)/t32-/m0/s1
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InChIKey
JWHNDKULDYVLMW-YTTGMZPUSA-N
Physicochemical Property
logP
6.56482
Rotatable Bonds
9
Heavy Atom Count
45
Polar Areas
96.77
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155561761
ChEMBL ID
CHEMBL4582290
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01286, Bile acid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
IC50 = 2690 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 38700 nM