General Information of the Compound
Compound ID
CP0183634
Compound Name
N-[(2S)-5-[3,5-bis(trifluoromethyl)phenyl]-1-(1H-indol-3-yl)-3-oxopentan-2-yl]-2-morpholin-4-ylacetamide
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Structure
Formula
C27H27F6N3O3
Molecular Weight
555.519
Canonical SMILES
FC(F)(F)c1cc(CCC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CN2CCOCC2)cc(c1)C(F)(F)F
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InChI
InChI=1S/C27H27F6N3O3/c28-26(29,30)19-11-17(12-20(14-19)27(31,32)33)5-6-24(37)23(35-25(38)16-36-7-9-39-10-8-36)13-18-15-34-22-4-2-1-3-21(18)22/h1-4,11-12,14-15,23,34H,5-10,13,16H2,(H,35,38)/t23-/m0/s1
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InChIKey
MXOFDARLDVKZQB-QHCPKHFHSA-N
Physicochemical Property
logP
4.7669
Rotatable Bonds
9
Heavy Atom Count
39
Polar Areas
74.43
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11757401
SID: 16865178
ChEMBL ID
CHEMBL173231
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  3
1
IC50 = 2 nM
   TI
   LI
   LO
   TS
2
IC50 = 3.5 nM
   TI
   LI
   LO
   TS
3
IC50 = 4 nM
   TI
   LI
   LO
   TS