General Information of the Compound
Compound ID
CP0178626
Compound Name
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(4S)-2-[2-[benzyl(2-methylpropyl)amino]-2-oxoethyl]-3-oxo-4,5-dihydro-1H-2-benzazepin-4-yl]-5-(diaminomethylideneamino)pentanamide
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Structure
Formula
C40H54N8O5
Molecular Weight
726.923
Canonical SMILES
CC(C)CN(Cc1ccccc1)C(=O)CN1Cc2ccccc2C[C@H](NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](N)Cc2c(C)cc(O)cc2C)C1=O
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InChI
InChI=1S/C40H54N8O5/c1-25(2)21-47(22-28-11-6-5-7-12-28)36(50)24-48-23-30-14-9-8-13-29(30)19-35(39(48)53)46-38(52)34(15-10-16-44-40(42)43)45-37(51)33(41)20-32-26(3)17-31(49)18-27(32)4/h5-9,11-14,17-18,25,33-35,49H,10,15-16,19-24,41H2,1-4H3,(H,45,51)(H,46,52)(H4,42,43,44)/t33-,34+,35-/m0/s1
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InChIKey
HQVRNLIDCXUVHE-XFQWPLCWSA-N
Physicochemical Property
logP
2.38141
Rotatable Bonds
16
Heavy Atom Count
53
Polar Areas
206.97
Hydrogen Bond Donor Count
7
Hydrogen Bond Acceptor Count
7
Complexity
53

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118731115
ChEMBL ID
CHEMBL3408732
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 1020 nM
   TI
   LI
   LO
   TS