General Information of the Compound
Compound ID
CP0173162
Compound Name
(2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
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Structure
Formula
C20H20ClN3O5S
Molecular Weight
449.916
Canonical SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2nnc(s2)-c2ccccn2)c1
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InChI
InChI=1S/C20H20ClN3O5S/c21-12-5-4-10(19-18(28)17(27)16(26)14(9-25)29-19)7-11(12)8-15-23-24-20(30-15)13-3-1-2-6-22-13/h1-7,14,16-19,25-28H,8-9H2/t14-,16-,17+,18-,19+/m1/s1
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InChIKey
CQCPCQSVBVILAS-FTWQHDNSSA-N
Physicochemical Property
logP
1.3592
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
128.82
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
9
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46229295
SID: 104174614
ChEMBL ID
CHEMBL590296
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02415, Sodium/glucose cotransporter 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 30.3 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 30.3 nM