General Information of the Compound
Compound ID
CP0169183
Compound Name
2-[5-bromo-2-cyclopropyl-3-(5-methoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)indol-1-yl]-N-(1-prop-2-enoylazetidin-3-yl)acetamide
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Structure
Formula
C30H31BrN4O4
Molecular Weight
591.506
Canonical SMILES
COc1cccc2CN(CCc12)C(=O)c1c(C2CC2)n(CC(=O)NC2CN(C2)C(=O)C=C)c2ccc(Br)cc12
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InChI
InChI=1S/C30H31BrN4O4/c1-3-27(37)34-15-21(16-34)32-26(36)17-35-24-10-9-20(31)13-23(24)28(29(35)18-7-8-18)30(38)33-12-11-22-19(14-33)5-4-6-25(22)39-2/h3-6,9-10,13,18,21H,1,7-8,11-12,14-17H2,2H3,(H,32,36)
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InChIKey
UVXRQALKQIHAOZ-UHFFFAOYSA-N
Physicochemical Property
logP
4.0013
Rotatable Bonds
7
Heavy Atom Count
39
Polar Areas
83.88
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 146585895
ChEMBL ID
CHEMBL4579956
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03462, GTPase KRas
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000207 MIA PaCa-2 Homo sapiens (Human)  1
1
IC50 = 604 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 139 nM