General Information of the Compound
Compound ID
CP0167222
Compound Name
3-(3-(4-(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imidazol-1-yl)phenoxy)propyl)thiazolidine
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Structure
Formula
C24H23FN4OS
Molecular Weight
434.54
Canonical SMILES
Fc1ccc2n(c(nc2c1)-c1ccccn1)-c1ccc(OCCCN2CCSC2)cc1
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InChI
InChI=1S/C24H23FN4OS/c25-18-5-10-23-22(16-18)27-24(21-4-1-2-11-26-21)29(23)19-6-8-20(9-7-19)30-14-3-12-28-13-15-31-17-28/h1-2,4-11,16H,3,12-15,17H2
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InChIKey
LKRTVYMJTLSROG-UHFFFAOYSA-N
Physicochemical Property
logP
5.0018
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
43.18
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11532153
SID: 16634190
ChEMBL ID
CHEMBL496523
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 20 nM
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