General Information of the Compound
Compound ID
CP0167039
Compound Name
2-(4-chloro-6-((5-(4-(trifluoromethyl)phenyl)isoxazol-3-yl)methoxy)benzo[b]thiophen-3-yl)acetic acid
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Structure
Formula
C21H13ClF3NO4S
Molecular Weight
467.852
Canonical SMILES
OC(=O)Cc1csc2cc(OCc3cc(on3)-c3ccc(cc3)C(F)(F)F)cc(Cl)c12
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InChI
InChI=1S/C21H13ClF3NO4S/c22-16-7-15(8-18-20(16)12(10-31-18)5-19(27)28)29-9-14-6-17(30-26-14)11-1-3-13(4-2-11)21(23,24)25/h1-4,6-8,10H,5,9H2,(H,27,28)
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InChIKey
NYCOHPNFMJTKMD-UHFFFAOYSA-N
Physicochemical Property
logP
6.4346
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
72.56
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 22504835
ChEMBL ID
CHEMBL393765
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00909, Peroxisome proliferator-activated receptor delta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 2360 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 97 nM