General Information of the Compound
Compound ID
CP0165287
Compound Name
(2R,4aS,10aR)-4a-benzyl-2-(prop-1-ynyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-2,7-diol
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Synonyms
(2R,4aS,10aR)-4a-benzyl-2-(prop-1-ynyl)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-2,7-diol
BDBM50113780
CHEMBL78625
CP-409069
SCHEMBL3114566
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Structure
Formula
C24H26O2
Molecular Weight
346.47
Canonical SMILES
CC#C[C@@]1(O)CC[C@]2(Cc3ccccc3)[C@H](CCc3cc(O)ccc23)C1
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InChI
InChI=1S/C24H26O2/c1-2-12-23(26)13-14-24(16-18-6-4-3-5-7-18)20(17-23)9-8-19-15-21(25)10-11-22(19)24/h3-7,10-11,15,20,25-26H,8-9,13-14,16-17H2,1H3/t20-,23-,24+/m1/s1
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InChIKey
WDSPVCXWXOIFRA-HUVFLSCGSA-N
Physicochemical Property
logP
4.3734
Rotatable Bonds
2
Heavy Atom Count
26
Polar Areas
40.46
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 9819614
SID: 14778301
ChEMBL ID
CHEMBL78625
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000229 SW1353 Homo sapiens (Human)  2
1
Ki = 4 nM
   TI
   LI
   LO
   TS
2
Ki = 5.5 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.17 nM
Clinical Information about the Compound
Drug 1 ( CP-409069 )
Drug Name CP-409069
Target(s)
Androgen receptor messenger RNA (AR mRNA)
Inhibitor
Estrogen receptor (ESR)
Inhibitor
Estrogen receptor beta (ESR2)
Inhibitor
Glucocorticoid receptor messenger RNA (GCR mRNA)
Inhibitor