General Information of the Compound
| Compound ID |
CP0161707
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| Compound Name |
4-(8-methoxy-5,6-dihydrobenzo[h]quinazolin-2-ylamino)benzenesulfonamide
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| Structure |
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| Formula |
C19H18N4O3S
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| Molecular Weight |
382.445
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| Canonical SMILES |
COc1ccc-2c(CCc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc-23)c1
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| InChI |
InChI=1S/C19H18N4O3S/c1-26-15-6-9-17-12(10-15)2-3-13-11-21-19(23-18(13)17)22-14-4-7-16(8-5-14)27(20,24)25/h4-11H,2-3H2,1H3,(H2,20,24,25)(H,21,22,23)
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| InChIKey |
LZHPQDAZPOPFGO-UHFFFAOYSA-N
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| Physicochemical Property |
"RO5" indicates the cutoff set by lipinski's rule of five: (1) Molecular weight less than 500 Dalton; (2) xlogp less than 5; (3) No more than 5 hbonddonor (Hydrogen Bond Donor Count); (4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count); (5) No more than 10 rotbonds (Rotatable Bond Count). Show/Hide
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Map of Molecular Bioactivity Related to the Compound
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Map of Molecular Bioactivity Related to the Compound Compound Cell Line Protein Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity |
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Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00877, Inhibitor of nuclear factor kappa-B kinase subunit beta
Cell Viability or Cytotoxicity Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000323 | LoVo | Homo sapiens (Human) | 1 |
| 1 |
IC50 = 750 nM
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TI
LI
LO
TS
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