General Information of the Compound
Compound ID
CP0160000
Compound Name
2-(8-(4-(4-(trifluoromethyl)benzyloxy)benzylthio)-6-methylchroman-5-yloxy)acetic acid
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Structure
Formula
C27H25F3O5S
Molecular Weight
518.553
Canonical SMILES
Cc1cc(SCc2ccc(OCc3ccc(cc3)C(F)(F)F)cc2)c2OCCCc2c1OCC(O)=O
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InChI
InChI=1S/C27H25F3O5S/c1-17-13-23(26-22(3-2-12-33-26)25(17)35-15-24(31)32)36-16-19-6-10-21(11-7-19)34-14-18-4-8-20(9-5-18)27(28,29)30/h4-11,13H,2-3,12,14-16H2,1H3,(H,31,32)
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InChIKey
KOEHFAAAJFPVKP-UHFFFAOYSA-N
Physicochemical Property
logP
6.67352
Rotatable Bonds
9
Heavy Atom Count
36
Polar Areas
64.99
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 22280114
ChEMBL ID
CHEMBL391479
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00909, Peroxisome proliferator-activated receptor delta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 313 nM