General Information of the Compound
Compound ID
CP0158747
Compound Name
2,4-dichloro-N-(3,5-dichloro-4-quinolin-3-yloxyphenyl)benzenesulfonamide
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Synonyms
C541917000
INT131
PMID25416646-Compound-Figure2-K
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Structure
Formula
C21H12Cl4N2O3S
Molecular Weight
514.217
Canonical SMILES
Clc1ccc(c(Cl)c1)S(=O)(=O)Nc1cc(Cl)c(Oc2cnc3ccccc3c2)c(Cl)c1
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InChI
InChI=1S/C21H12Cl4N2O3S/c22-13-5-6-20(16(23)8-13)31(28,29)27-14-9-17(24)21(18(25)10-14)30-15-7-12-3-1-2-4-19(12)26-11-15/h1-11,27H
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InChIKey
NMRWDFUZLLQSBN-UHFFFAOYSA-N
CAS
315224-26-1
Physicochemical Property
logP
7.4415
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
68.29
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10229498
SID: 15230477
ChEMBL ID
CHEMBL1236924
DrugBank ID
DB05490
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00915, Peroxisome proliferator-activated receptor gamma
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  3
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
2
EC50 = 150 nM
   TI
   LI
   LO
   TS
3
Ki = 10 nM
   TI
   LI
   LO
   TS
CL000065 HEK293-EBNA Homo sapiens (Human)  1
1
EC50 = 59 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T Homo sapiens (Human)  1
1
EC50 = 170 nM
   TI
   LI
   LO
   TS
CL000413 MKN45 Homo sapiens (Human)  1
1
EC50 > 500 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 17 nM
2 Ki = 10 nM
Clinical Information about the Compound
Drug 1 ( INT131 )
Drug Name INT131
Company InteKrin Therapeutics
Indication
Type-2 diabetes
Phase 2
Drug 2 ( PMID25416646-Compound-Figure2-K )
Drug Name PMID25416646-Compound-Figure2-K
Company INTEKRIN THERAPEUTICS, INC
Target(s)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma)
Agonist