General Information of the Compound
Compound ID
CP0152601
Compound Name
(S)-2-chloro-4-((1-isopropyl-5-oxopyrrolidin-3-yl)(2-methylbenzyl)amino)benzonitrile
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Structure
Formula
C22H24ClN3O
Molecular Weight
381.907
Canonical SMILES
CC(C)N1C[C@H](CC1=O)N(Cc1ccccc1C)c1ccc(C#N)c(Cl)c1
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InChI
InChI=1S/C22H24ClN3O/c1-15(2)25-14-20(11-22(25)27)26(13-18-7-5-4-6-16(18)3)19-9-8-17(12-24)21(23)10-19/h4-10,15,20H,11,13-14H2,1-3H3/t20-/m0/s1
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InChIKey
JZLOVKHBMOYULJ-FQEVSTJZSA-N
Physicochemical Property
logP
4.536
Rotatable Bonds
5
Heavy Atom Count
27
Polar Areas
47.34
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45272012
ChEMBL ID
CHEMBL551541
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
EC50 = 2 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 20 nM