General Information of the Compound
Compound ID
CP0147508
Compound Name
N-hydroxynaphthalene-1-carboxamide
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Synonyms
.alpha.-Naphthohydroxamic acid
1-NAPHTHALENECARBOXAMIDE, N-HYDROXY-
1-Naphthohydroxamic acid
4-09-00-02407 (Beilstein Handbook Reference)
6953-61-3
8GK
AC1L2M8D
ACMC-209o98
BRN 2094470
CHEMBL115468
CTK5D0341
DTXSID30219789
JRZGPWOEHDOVMC-UHFFFAOYSA-N
N-Hydroxy-1-naphthamide
N-Hydroxy-1-naphthamide #
N-Hydroxynaphthalene-1-carboxamide
N-hydroxy-1-naphthamide
NSC 57457
Naphthalene-1-carboxylic acid hydroxyamide
SCHEMBL2230679
a-Naphthohydroxamic acid
alpha-Naphthohydroxamic acid
naphthylhydroxamic acid
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Structure
Formula
C11H9NO2
Molecular Weight
187.198
Canonical SMILES
ONC(=O)c1cccc2ccccc12
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InChI
InChI=1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)
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InChIKey
JRZGPWOEHDOVMC-UHFFFAOYSA-N
CAS
6953-61-3
Physicochemical Property
logP
1.9588
Rotatable Bonds
1
Heavy Atom Count
14
Polar Areas
49.33
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Complexity
14

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 23382
SID: 15322198
ChEMBL ID
CHEMBL115468
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01743, Polyunsaturated fatty acid 5-lipoxygenase
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000194 RBL-1
 Cell Line Info 
Rattus norvegicus (Rat)  1
1
IC50 = 43000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( N-hydroxy-1-naphthamide )
Drug Name N-hydroxy-1-naphthamide
Target(s)
Histone deacetylase 8 (HDAC8)
 Target Info 
Inhibitor