General Information of the Compound
Compound ID
CP0144199
Compound Name
(S)-2-chloro-4-((2-cyanobenzyl)(1-(methylsulfonyl)pyrrolidin-3-yl)amino)benzonitrile
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Structure
Formula
C20H19ClN4O2S
Molecular Weight
414.918
Canonical SMILES
CS(=O)(=O)N1CC[C@@H](C1)N(Cc1ccccc1C#N)c1ccc(C#N)c(Cl)c1
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InChI
InChI=1S/C20H19ClN4O2S/c1-28(26,27)24-9-8-19(14-24)25(13-17-5-3-2-4-15(17)11-22)18-7-6-16(12-23)20(21)10-18/h2-7,10,19H,8-9,13-14H2,1H3/t19-/m0/s1
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InChIKey
VULXLZZXKAOWKQ-IBGZPJMESA-N
Physicochemical Property
logP
3.12386
Rotatable Bonds
5
Heavy Atom Count
28
Polar Areas
88.2
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46224683
ChEMBL ID
CHEMBL590835
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
EC50 = 1130 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 100 nM