General Information of the Compound
Compound ID
CP0143835
Compound Name
1-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-3-methoxypyridin-4-one
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Formula
C21H26N2O3
Molecular Weight
354.45
Canonical SMILES
COc1cn(ccc1=O)-c1ccc(OC2CCN(CC2)C2CCC2)cc1
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InChI
InChI=1S/C21H26N2O3/c1-25-21-15-23(14-11-20(21)24)17-5-7-18(8-6-17)26-19-9-12-22(13-10-19)16-3-2-4-16/h5-8,11,14-16,19H,2-4,9-10,12-13H2,1H3
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InChIKey
JUJZTPKDMIGHQU-UHFFFAOYSA-N
Physicochemical Property
logP
3.2418
Rotatable Bonds
5
Heavy Atom Count
26
Polar Areas
43.7
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4763867
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01194, Histamine H3 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 0.74 nM
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