General Information of the Compound
Compound ID
CP0139026
Compound Name
3-[(1S)-1-(1,6-dimethylbenzimidazol-2-yl)-2-(1-propan-2-ylsulfonylpiperidin-4-yl)ethyl]-1-(4-phenoxyphenyl)imidazolidine-2,4-dione
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Structure
Formula
C34H39N5O5S
Molecular Weight
629.783
Canonical SMILES
CC(C)S(=O)(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccc(C)cc3n2C)CC1
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InChI
InChI=1S/C34H39N5O5S/c1-23(2)45(42,43)37-18-16-25(17-19-37)21-31(33-35-29-15-10-24(3)20-30(29)36(33)4)39-32(40)22-38(34(39)41)26-11-13-28(14-12-26)44-27-8-6-5-7-9-27/h5-15,20,23,25,31H,16-19,21-22H2,1-4H3/t31-/m0/s1
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InChIKey
IFSUFKIWOFTARK-HKBQPEDESA-N
Physicochemical Property
logP
6.02422
Rotatable Bonds
9
Heavy Atom Count
45
Polar Areas
105.05
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155523526
ChEMBL ID
CHEMBL4454185
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01286, Bile acid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
IC50 = 59.8 nM
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