General Information of the Compound
Compound ID
CP0137549
Compound Name
3-methylbutyl N-[3-[3-(imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamate
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Structure
Formula
C24H31N3O4S2
Molecular Weight
489.663
Canonical SMILES
CC(C)CCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1cccc(Cn2ccnc2)c1
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InChI
InChI=1S/C24H31N3O4S2/c1-17(2)8-11-31-24(28)26-33(29,30)23-22(14-21(32-23)12-18(3)4)20-7-5-6-19(13-20)15-27-10-9-25-16-27/h5-7,9-10,13-14,16-18H,8,11-12,15H2,1-4H3,(H,26,28)
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InChIKey
VGBKYUXZYOSUIC-UHFFFAOYSA-N
Physicochemical Property
logP
5.3194
Rotatable Bonds
10
Heavy Atom Count
33
Polar Areas
90.29
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145978497
ChEMBL ID
CHEMBL4204342
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01553, Type-2 angiotensin II receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 230 nM
   TI
   LI
   LO
   TS