General Information of the Compound
Compound ID
CP0132914
Compound Name
N-[5-[4-[(5-tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-1H-pyrazol-3-yl]-2,2-dimethylpropanamide
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Structure
Formula
C22H28N6O3
Molecular Weight
424.505
Canonical SMILES
CC(C)(C)C(=O)Nc1cc([nH]n1)-c1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1
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InChI
InChI=1S/C22H28N6O3/c1-21(2,3)16-12-18(28-31-16)25-20(30)23-14-9-7-13(8-10-14)15-11-17(27-26-15)24-19(29)22(4,5)6/h7-12H,1-6H3,(H2,23,25,28,30)(H2,24,26,27,29)
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InChIKey
XNKCXSVBIUSWQP-UHFFFAOYSA-N
Physicochemical Property
logP
4.9908
Rotatable Bonds
4
Heavy Atom Count
31
Polar Areas
124.94
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 127045224
ChEMBL ID
CHEMBL3809608
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 = 390 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 310 nM