General Information of the Compound
Compound ID
CP0122257
Compound Name
4-[(E)-2-[3-(4-hydroxy-3-methoxyphenyl)-1H-pyrazol-5-yl]ethenyl]-2-methoxyphenol
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Structure
Formula
C19H18N2O4
Molecular Weight
338.363
Canonical SMILES
COc1cc(\C=C\c2cc([nH]n2)-c2ccc(O)c(OC)c2)ccc1O
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InChI
InChI=1S/C19H18N2O4/c1-24-18-9-12(4-7-16(18)22)3-6-14-11-15(21-20-14)13-5-8-17(23)19(10-13)25-2/h3-11,22-23H,1-2H3,(H,20,21)/b6-3+
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InChIKey
UZZQRMKZEWWBQZ-ZZXKWVIFSA-N
Physicochemical Property
logP
3.6755
Rotatable Bonds
5
Heavy Atom Count
25
Polar Areas
87.6
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
25

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 136244569
ChEMBL ID
CHEMBL2413471
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01503, Signal transducer and activator of transcription 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000150 HaCaT Homo sapiens (Human)  1
1
IC50 = 18200 nM
   TI
   LI
   LO
   TS
Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS