General Information of the Compound
Compound ID
CP0103789
Compound Name
2-(7-(4-(4-tert-butylbenzyloxy)benzylthio)-2,3-dihydro-1H-inden-4-yloxy)acetic acid
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Structure
Formula
C29H32O4S
Molecular Weight
476.638
Canonical SMILES
CC(C)(C)c1ccc(COc2ccc(CSc3ccc(OCC(O)=O)c4CCCc34)cc2)cc1
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InChI
InChI=1S/C29H32O4S/c1-29(2,3)22-11-7-20(8-12-22)17-32-23-13-9-21(10-14-23)19-34-27-16-15-26(33-18-28(30)31)24-5-4-6-25(24)27/h7-16H,4-6,17-19H2,1-3H3,(H,30,31)
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InChIKey
SNUCWTMFDGLTCI-UHFFFAOYSA-N
Physicochemical Property
logP
6.8075
Rotatable Bonds
9
Heavy Atom Count
34
Polar Areas
55.76
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 22280210
ChEMBL ID
CHEMBL392949
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00909, Peroxisome proliferator-activated receptor delta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 267 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 148 nM