General Information of the Compound
Compound ID
CP0103788
Compound Name
2-(7-(2-(4-(trifluoromethyl)benzyloxy)-5-fluorobenzylthio)-2,3-dihydro-1H-inden-4-yloxy)acetic acid
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Structure
Formula
C26H22F4O4S
Molecular Weight
506.517
Canonical SMILES
OC(=O)COc1ccc(SCc2cc(F)ccc2OCc2ccc(cc2)C(F)(F)F)c2CCCc12
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InChI
InChI=1S/C26H22F4O4S/c27-19-8-9-22(33-13-16-4-6-18(7-5-16)26(28,29)30)17(12-19)15-35-24-11-10-23(34-14-25(31)32)20-2-1-3-21(20)24/h4-12H,1-3,13-15H2,(H,31,32)
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InChIKey
OKTZSQCGQXXCKS-UHFFFAOYSA-N
Physicochemical Property
logP
6.6679
Rotatable Bonds
9
Heavy Atom Count
35
Polar Areas
55.76
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 23628247
SID: 46489382
ChEMBL ID
CHEMBL232400
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00909, Peroxisome proliferator-activated receptor delta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 70 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.7 nM