General Information of the Compound
Compound ID
CP0092026
Compound Name
4-N-methyl-2-N,4-N-bis(2-methylpropyl)-6-(2-naphthalen-1-ylethyl)pyrimidine-2,4-diamine
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Structure
Formula
C25H34N4
Molecular Weight
390.575
Canonical SMILES
CC(C)CNc1nc(CCc2cccc3ccccc23)cc(n1)N(C)CC(C)C
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InChI
InChI=1S/C25H34N4/c1-18(2)16-26-25-27-22(15-24(28-25)29(5)17-19(3)4)14-13-21-11-8-10-20-9-6-7-12-23(20)21/h6-12,15,18-19H,13-14,16-17H2,1-5H3,(H,26,27,28)
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InChIKey
JCTTXRHAVWZMKY-UHFFFAOYSA-N
Physicochemical Property
logP
5.5751
Rotatable Bonds
9
Heavy Atom Count
29
Polar Areas
41.05
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25129167
SID: 56453482
ChEMBL ID
CHEMBL495326
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00886, Estrogen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000209 HEC-1 Homo sapiens (Human)  1
1
IC50 = 4400 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 2400 nM