General Information of the Compound
Compound ID
CP0090929
Compound Name
N-[1-[[(3S,4R)-1-(cyclopentanecarbonyl)-4-hydroxy-4-phenylpyrrolidin-3-yl]methyl]piperidin-4-yl]-N-prop-2-enyl-2-(4-sulfamoylphenyl)acetamide
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Structure
Formula
C33H44N4O5S
Molecular Weight
608.805
Canonical SMILES
NS(=O)(=O)c1ccc(CC(=O)N(CC=C)C2CCN(C[C@H]3CN(C[C@]3(O)c3ccccc3)C(=O)C3CCCC3)CC2)cc1
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InChI
InChI=1S/C33H44N4O5S/c1-2-18-37(31(38)21-25-12-14-30(15-13-25)43(34,41)42)29-16-19-35(20-17-29)22-28-23-36(32(39)26-8-6-7-9-26)24-33(28,40)27-10-4-3-5-11-27/h2-5,10-15,26,28-29,40H,1,6-9,16-24H2,(H2,34,41,42)/t28-,33-/m0/s1
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InChIKey
YJKZSHWCMHPIQM-UVMMSNCQSA-N
Physicochemical Property
logP
2.8919
Rotatable Bonds
10
Heavy Atom Count
43
Polar Areas
124.25
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44194589
SID: 85190403
ChEMBL ID
CHEMBL1172624
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 2.1 nM
   TI
   LI
   LO
   TS