General Information of the Compound
Compound ID
CP0090925
Compound Name
2,1,3-benzoxadiazol-5-ylmethyl N-[1-[[(3S,4R)-1-(cyclopentanecarbonyl)-4-hydroxy-4-phenylpyrrolidin-3-yl]methyl]piperidin-4-yl]-N-prop-2-enylcarbamate
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Structure
Formula
C33H41N5O5
Molecular Weight
587.721
Canonical SMILES
O[C@@]1(CN(C[C@@H]1CN1CCC(CC1)N(CC=C)C(=O)OCc1ccc2nonc2c1)C(=O)C1CCCC1)c1ccccc1
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InChI
InChI=1S/C33H41N5O5/c1-2-16-38(32(40)42-22-24-12-13-29-30(19-24)35-43-34-29)28-14-17-36(18-15-28)20-27-21-37(31(39)25-8-6-7-9-25)23-33(27,41)26-10-4-3-5-11-26/h2-5,10-13,19,25,27-28,41H,1,6-9,14-18,20-23H2/t27-,33-/m0/s1
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InChIKey
FVLUABNJOZKWTR-CMVGPNDKSA-N
Physicochemical Property
logP
4.3482
Rotatable Bonds
9
Heavy Atom Count
43
Polar Areas
112.24
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44194496
SID: 85190308
ChEMBL ID
CHEMBL1172041
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 113.6 nM
   TI
   LI
   LO
   TS