General Information of the Compound
Compound ID
CP0084055
Compound Name
(E)-3-[5'-(Adamant-1-yl)-2-chloro-4'-[(2-methoxyethoxy)methoxy]-2'-methylbiphenyl-4-yl]acrylic acid
    Show/Hide
Structure
Formula
C30H35ClO5
Molecular Weight
511.058
Canonical SMILES
COCCOCOc1cc(C)c(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc(\C=C\C(O)=O)cc1Cl
    Show/Hide
InChI
InChI=1S/C30H35ClO5/c1-19-9-28(36-18-35-8-7-34-2)26(30-15-21-10-22(16-30)12-23(11-21)17-30)14-25(19)24-5-3-20(13-27(24)31)4-6-29(32)33/h3-6,9,13-14,21-23H,7-8,10-12,15-18H2,1-2H3,(H,32,33)/b6-4+
    Show/Hide
InChIKey
FVDNFTXROHQVTA-GQCTYLIASA-N
Physicochemical Property
logP
6.88032
Rotatable Bonds
10
Heavy Atom Count
36
Polar Areas
64.99
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44127468
ChEMBL ID
CHEMBL564563
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03152, Retinoic acid receptor RXR-alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  1
1
EC50 = 600 nM
   TI
   LI
   LO
   TS