General Information of the Compound
Compound ID
CP0083527
Compound Name
2-(4-methyl-6-((5-(4-(trifluoromethyl)phenyl)isoxazol-3-yl)methoxy)benzo[b]thiophen-3-yl)acetic acid
    Show/Hide
Structure
Formula
C22H16F3NO4S
Molecular Weight
447.434
Canonical SMILES
Cc1cc(OCc2cc(on2)-c2ccc(cc2)C(F)(F)F)cc2scc(CC(O)=O)c12
    Show/Hide
InChI
InChI=1S/C22H16F3NO4S/c1-12-6-17(9-19-21(12)14(11-31-19)7-20(27)28)29-10-16-8-18(30-26-16)13-2-4-15(5-3-13)22(23,24)25/h2-6,8-9,11H,7,10H2,1H3,(H,27,28)
    Show/Hide
InChIKey
ONHPYXIGAYSAKE-UHFFFAOYSA-N
Physicochemical Property
logP
6.08962
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
72.56
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 22504815
ChEMBL ID
CHEMBL234382
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00909, Peroxisome proliferator-activated receptor delta
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 561 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 37 nM