General Information of the Compound
Compound ID
CP0083036
Compound Name
2-{[2-({[2-(1-methylpyrrolidin-2-yl)ethyl]carbamoyl}amino)benzene]sulfonamido}-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
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Structure
Formula
C25H32N4O5S
Molecular Weight
500.621
Canonical SMILES
CN1CCCC1CCNC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
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InChI
InChI=1S/C25H32N4O5S/c1-29-16-6-8-18(29)14-15-26-25(32)27-20-10-4-5-11-22(20)35(33,34)28-21-13-12-17-7-2-3-9-19(17)23(21)24(30)31/h4-5,10-13,18,28H,2-3,6-9,14-16H2,1H3,(H,30,31)(H2,26,27,32)
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InChIKey
CHWSPBPQRLZHPM-UHFFFAOYSA-N
Physicochemical Property
logP
3.6702
Rotatable Bonds
8
Heavy Atom Count
35
Polar Areas
127.84
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
5
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11649022
SID: 16752412
ChEMBL ID
CHEMBL211997
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00973, Methionine aminopeptidase 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000156 HT-1080 Homo sapiens (Human)  1
1
EC50 = 1900 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 72 nM
2 IC50 = 500 nM