General Information of the Compound
Compound ID
CP0076249
Compound Name
TOFOGLIFLOZIN
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Synonyms
554245W62T
903565-83-3
AKOS027250822
BDBM50396779
CHEBI:136041
CHEMBL2110731
CSG 452
CSG-452
CSG452;CSG-452
DB11824
DTXSID90238097
EC 619-989-0
GTPL9395
KB-76204
MolPort-044-723-920
NCGC00485920-01
R-7201
SB11170
SCHEMBL903156
TOFOGLIFLOZIN
Tofogliflozin
Tofogliflozin [INN]
Tofogliflozin anhydrous
Tofogliflozin anyhydrous
Tube107
UNII-554245W62T
ZINC35826342
apleway
compound 16d [PMID: 22889351]
deberza
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Structure
Formula
C22H26O6
Molecular Weight
386.444
Canonical SMILES
CCc1ccc(Cc2ccc3CO[C@]4(O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c3c2)cc1
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InChI
InChI=1S/C22H26O6/c1-2-13-3-5-14(6-4-13)9-15-7-8-16-12-27-22(17(16)10-15)21(26)20(25)19(24)18(11-23)28-22/h3-8,10,18-21,23-26H,2,9,11-12H2,1H3/t18-,19-,20+,21-,22+/m1/s1
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InChIKey
VWVKUNOPTJGDOB-BDHVOXNPSA-N
CAS
903565-83-3
Physicochemical Property
logP
0.9966
Rotatable Bonds
4
Heavy Atom Count
28
Polar Areas
99.38
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46908929
ChEMBL ID
CHEMBL2110731
DrugBank ID
DB11824
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03804, Sodium/glucose cotransporter 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 8444 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 8444 nM
Protein ID: PT02415, Sodium/glucose cotransporter 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 2.9 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2.9 nM
2 IC50 = 4 nM
Clinical Information about the Compound
Drug 1 ( Tofogliflozin )
Drug Name Tofogliflozin
Company Genentech
Indication
Type-2 diabetes
Approved