General Information of the Compound
Compound ID
CP0072068
Compound Name
6-(3-chloro-4-cyclopropyloxyphenyl)pyrimidine-4-carboxylic acid
    Show/Hide
Structure
Formula
C14H11ClN2O3
Molecular Weight
290.706
Canonical SMILES
OC(=O)c1cc(ncn1)-c1ccc(OC2CC2)c(Cl)c1
    Show/Hide
InChI
InChI=1S/C14H11ClN2O3/c15-10-5-8(1-4-13(10)20-9-2-3-9)11-6-12(14(18)19)17-7-16-11/h1,4-7,9H,2-3H2,(H,18,19)
    Show/Hide
InChIKey
UPKQDTLLVVTZQT-UHFFFAOYSA-N
Physicochemical Property
logP
3.0364
Rotatable Bonds
4
Heavy Atom Count
20
Polar Areas
72.31
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
20

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 71282644
SID: 163497409
ChEMBL ID
CHEMBL3407922
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02724, Kynurenine 3-monooxygenase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.5 nM
2 IC50 = 82 nM