General Information of the Compound
Compound ID
CP0071969
Compound Name
Menthol
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Synonyms
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
2-Isopropyl-5-methylcyclohexanol
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
Cis-1 ,3-trans-1,4-(+-)-menthol
Cis-1,3-trans-1,4-(+-)-menthol
D,l-Menthol
D-(-)-Menthol
D-Menthol
D-Neomenthol
D-p-Menthan-3-ol
Dl-3-p-Menthanol
Dl-Menthol
Dl-Menthol (JP15)
Fisherman's friend lozenges
Fisherman's friendlozenges (TN)
Headache crystals
Hexahydrothymol
L-(-)-Menthol
L-Menthol
L-Menthol (JP15)
L-Menthol (TN)
L-Menthol (natural)
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
M0321
M0545
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
NOOLISFMXDJSKH-KXUCPTDWBX
Neoisomenthol
P-Menthan-3-ol
Peppermint camphor
RACEMIC MENTHOL U.S.PRac-Menthol
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
Tra-kill tracheal mite killer
U.S.P. Menthol
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Structure
Formula
C10H20O
Molecular Weight
156.269
Canonical SMILES
CC(C)C1CCC(C)CC1O
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InChI
InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3
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InChIKey
NOOLISFMXDJSKH-UHFFFAOYSA-N
CAS
20747-49-3
1490-04-6
491-02-1
15356-70-4
63975-60-0
Physicochemical Property
logP
2.4395
Rotatable Bonds
1
Heavy Atom Count
11
Polar Areas
20.23
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
1
Complexity
11

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 1254
SID: 15194819
ChEMBL ID
CHEMBL256087
DrugBank ID
DB14123
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04242, Transient receptor potential cation channel subfamily A member 1
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
EC50 = 95000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT03065, Transient receptor potential cation channel subfamily M member 8
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 3000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Menthol )
Drug Name Menthol
Indication
Throat irritation
Approved
Target(s)
Transformation-sensitive protein p120 (TRPA1)
 Target Info 
Activator
Long transient receptor potential channel 8 (TRPM8)
 Target Info 
Activator