General Information of the Compound
Compound ID
CP0070442
Compound Name
2-[5'-(Adamant-1-yl)-2-chloro-4'-[(2-methoxyethoxy)methoxy]-2'-methylbiphenyl-4-yl]acetic Acid
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Structure
Formula
C29H35ClO5
Molecular Weight
499.047
Canonical SMILES
COCCOCOc1cc(C)c(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc(CC(O)=O)cc1Cl
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InChI
InChI=1S/C29H35ClO5/c1-18-7-27(35-17-34-6-5-33-2)25(29-14-20-8-21(15-29)10-22(9-20)16-29)13-24(18)23-4-3-19(11-26(23)30)12-28(31)32/h3-4,7,11,13,20-22H,5-6,8-10,12,14-17H2,1-2H3,(H,31,32)
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InChIKey
HDBFHIYGUZDEQB-UHFFFAOYSA-N
Physicochemical Property
logP
6.40962
Rotatable Bonds
10
Heavy Atom Count
35
Polar Areas
64.99
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44127258
ChEMBL ID
CHEMBL560351
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03152, Retinoic acid receptor RXR-alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1 Chlorocebus aethiops (Green monkey)  1
1
EC50 = 1137 nM
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