General Information of the Compound
Compound ID
CP0052082
Compound Name
4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoylbenzamide
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Synonyms
1-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline
3-(Aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)benzamide
4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide
4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide
Apo-Indapamide
Arifon
Bajaten
Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-(9CI)
Cormil
Damide
Fludex
Idapamide
Indaflex
Indamol
Indapamida
Indapamida [INN-Spanish]
Indapamide
Indapamide (JAN/USP)
Indapamide (USP)
Indapamide [USAN:INN:BAN:JAN]
Indapamidum
Indapamidum [INN-Latin]
Ipamix
Lozide
Lozol
Lozol (TN)
Metindamide
N-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline
N-[4-Chloro-3-sulfamoylbenzamido]-2-methylindoline
NLozol, Arifon, Fludex, Noranat, Veroxil, Tertensif, Indapamide
Natrilix
Natrilix (TN)
Natrix
Natrix (TN)
Noranat
Novo-Indapamide
Nu-Indapamide
Pressurai
RHC 2555
S-1520
SE 1520
SE-1520
Tandix
Tertensif
USV 2555
Veroxil
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Structure
Formula
C16H16ClN3O3S
Molecular Weight
365.842
Canonical SMILES
CC1Cc2ccccc2N1NC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O
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InChI
InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)
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InChIKey
NDDAHWYSQHTHNT-UHFFFAOYSA-N
CAS
26807-65-8
49564-58-1
Physicochemical Property
logP
2.0834
Rotatable Bonds
3
Heavy Atom Count
24
Polar Areas
92.5
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 3702
SID: 14828553
ChEMBL ID
CHEMBL406
DrugBank ID
DB00808
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06109, Geminin
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000015 SW480
 Cell Line Info 
Homo sapiens (Human)  1
1
Potency ~ 1778.3 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Indapamide )
Drug Name Indapamide
Company Servier Laboratories
Indication
Hypertension
Approved
Target(s)
Voltage-gated potassium channel Kv7.1 (KCNQ1)
 Target Info 
Blocker