General Information of the Compound
Compound ID
CP0051480
Compound Name
4-(1,1-dioxo-1,2-thiazinan-2-yl)benzene-1-sulfonamide
    Show/Hide
Synonyms
4-(1,1-Dioxido-1,2-thiazinan-2-yl)benzenesulfonamide
4-(1,1-dioxothiazinan-2-yl)benzenesulfonamide
61-56-3
BRN 1222219
Bayer A-168
Benzenesulfonamide, 4-(tetrahydro-2H-1,2-thiazin-2-yl)-, S,S-dioxide
CHEMBL328560
Conadil
Contravul
EINECS 200-511-0
Elisal
Ospolot
R-594
RP 10284
RP-10284
Riker 594
SULTHIAME
Sulphenyltame
Sulthiame [USAN]
Sulthiamine
Sultiamo [INN-Spanish]
Sultiamum
Sultiamum [INN-Latin]
Trolone
UNII-I00Q766CZ2
p-(Tetrahydro-2H-1,2-thiazin-2-yl)benzenesulfonamide, S,S-dioxide
sultiam
sultiame
    Show/Hide
Structure
Formula
C10H14N2O4S2
Molecular Weight
290.366
Canonical SMILES
NS(=O)(=O)c1ccc(cc1)N1CCCCS1(=O)=O
    Show/Hide
InChI
InChI=1S/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16)
    Show/Hide
InChIKey
HMHVCUVYZFYAJI-UHFFFAOYSA-N
CAS
61-56-3
Physicochemical Property
logP
0.264
Rotatable Bonds
2
Heavy Atom Count
18
Polar Areas
97.54
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
18

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 5356
SID: 14800055
ChEMBL ID
CHEMBL328560
DrugBank ID
DB08329
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00209, Carbonic anhydrase
 Protein Info 
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 45.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 45.2 nM
Clinical Information about the Compound
Drug 1 ( SULTHIAME )
Drug Name SULTHIAME
Target(s)
Carbonic anhydrase II (CA-II)
 Target Info 
Inhibitor