General Information of the Compound
Compound ID
CP0042119
Compound Name
benzyl N-(1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)carbamate
    Show/Hide
Synonyms
GW841819X
KB-75882
    Show/Hide
Structure
Formula
C25H21N5O2
Molecular Weight
423.476
Canonical SMILES
Cc1nnc2C(NC(=O)OCc3ccccc3)N=C(c3ccccc3)c3ccccc3-n12
    Show/Hide
InChI
InChI=1S/C25H21N5O2/c1-17-28-29-24-23(27-25(31)32-16-18-10-4-2-5-11-18)26-22(19-12-6-3-7-13-19)20-14-8-9-15-21(20)30(17)24/h2-15,23H,16H2,1H3,(H,27,31)
    Show/Hide
InChIKey
TUWDLUFFAHHNEF-UHFFFAOYSA-N
Physicochemical Property
logP
4.35172
Rotatable Bonds
4
Heavy Atom Count
32
Polar Areas
81.4
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 13953710
SID: 123047641
ChEMBL ID
CHEMBL2153434
Clinical Information about the Compound
Drug 1 ( GW841819X )
Drug Name GW841819X
Target(s)
Bromodomain-containing protein 3 (BRD3)
Inhibitor
Bromodomain-containing protein 4 (BRD4)
Inhibitor
Bromodomain-containing protein 2 (BRD2)
Inhibitor