General Information of the Protein
Protein ID
PT01511
Protein Name
Bromodomain-containing protein 2
Secondarily
Protein Name
O27.1.1
Really interesting new gene 3 protein
Gene Name
BRD2
Secondarily
Gene Name
KIAA9001
RING3
Sequence
MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
    Show/Hide
Organism
Homo sapiens, Human
Protein Classification
Epigenetic regulator
>
Reader
>
Bromodomain
Function
May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.
    Show/Hide
Uniprot ID
Primary ID:
P25440

Secondarily ID:
A2AAU0
B0S7P0
B1AZT1
O00699
O00700
Q15310
Q5STC9
Q63HQ9
Q658Y7
Q6P3U2
Q969U4
    Show/Hide
Ensembl ID
ENSG00000204256
HGNC ID
HGNC:1103
Subcellular Location
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000059 , HuT 78
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0717935
 Compound Info 
rac-8-(((3R,4R)-3-((1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-methoxy)piperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)quinolin-2(1H)-one
   Show/Hide
C27H34N4O4S
  1
1
Kd = 630.96 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0199056
 Compound Info 
8-[[(3R,4R)-3-(cyclohexylmethoxy)piperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-one
   Show/Hide
C27H35N5O2
  1
1
Kd = 3162.28 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0651910
 Compound Info 
8-(((3R,4R)-3-((1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-methoxy)-1-methylpiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one
   Show/Hide
C27H35N5O4S
  1
1
Kd = 19952.62 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0058410
 Compound Info 
2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-3H-quinazolin-4-one
   Show/Hide
C20H22N2O5
  8
1 IC50 = 246 nM
2 IC50 = 251 nM
3 IC50 = 5697 nM
4 IC50 = 5780 nM
5 Kd = 206 nM
6 Kd = 251 nM
7 Kd = 5780 nM
8 Kd = 16900 nM
CP0101685
 Compound Info 
propan-2-yl N-[(2S,4R)-1-acetyl-6-(furan-2-yl)-2-methyl-3,4-dihydro-2H-quinolin-4-yl]carbamate
   Show/Hide
C20H24N2O4
  6
1 IC50 = 610 nM
2 IC50 = 2020 nM
3 Kd = 47 nM
4 Kd = 80 nM
5 Kd = 280.44 nM
6 Kd = 2188.61 nM
CP0651910
 Compound Info 
8-(((3R,4R)-3-((1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-methoxy)-1-methylpiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one
   Show/Hide
C27H35N5O4S
  1
1 IC50 > 50118.72 nM
Clinical Information about the Protein
Target 1 ( Bromodomain-containing protein 2 (BRD2) )
Target Type Clinical trial Target
Disease 2 Target-related Diseases  2
1 Prostate cancer [ICD-11: 2C82.0]
2 Acute myeloid leukaemia [ICD-11: 2A60]
Clinical Trial Drug(s) 2 Clinical Trial Drugs  2
1 ABBV-744
 Drug Info 
Phase 1
Prostate cancer
2 OTX-015
 Drug Info 
Phase 1/2
Acute myeloid leukaemia
Target 2 ( HUMAN bromodomain-containing protein 2 (BRD2) )
Target Type Unknown Type Target
Disease 1 Target-related Disease  1
1 Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y]
Investigative Drug(s) 2 Investigative Drugs  2
1 ABBV-744
 Drug Info 
Investigative
Coronavirus Disease 2019 (COVID-19)
2 JQ1
 Drug Info 
Investigative
Coronavirus Disease 2019 (COVID-19)