General Information of the Compound
Compound ID
CP0041453
Compound Name
N-(3-chloro-2-fluorophenyl)-7-methoxy-6-(morpholin-4-ylmethyl)quinazolin-4-amine
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Structure
Formula
C20H20ClFN4O2
Molecular Weight
402.857
Canonical SMILES
COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCOCC1
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InChI
InChI=1S/C20H20ClFN4O2/c1-27-18-10-17-14(9-13(18)11-26-5-7-28-8-6-26)20(24-12-23-17)25-16-4-2-3-15(21)19(16)22/h2-4,9-10,12H,5-8,11H2,1H3,(H,23,24,25)
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InChIKey
FCKWCFASCOSSIK-UHFFFAOYSA-N
Physicochemical Property
logP
4.0067
Rotatable Bonds
5
Heavy Atom Count
28
Polar Areas
59.51
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 122192382
ChEMBL ID
CHEMBL3623278
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00922, Epidermal growth factor receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000324 NCI-H3255 Homo sapiens (Human)  1
1
IC50 = 6.6 nM
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